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Article

Yeast Tdp1 and Rad1-Rad10 function as redundant pathways for repairing Top1 replicative damage.

Proceedings of the National Academy of Sciences of the United States of America - 15 Oct 2002

Vance John R, Wilson Thomas E

Abstract excerpt

When a replication fork collides with a DNA topoisomerase I (Top1) cleavage complex, the covalently bound enzyme must be removed from the DNA 3' end before recombination-dependent replication restart. Here we report that the tyrosyl-DNA phosphodiesterase Tdp1 and the structure-specific endonuclea...

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Source

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Identifiers

PMID: 12368472
DOI: 10.1073/pnas.202242599
PMCID: PMC129737

Genes

RAD50
RAD51
RAD52
TOP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-12368472-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Yeast Tdp1 and Rad1-Rad10 function as redundant pathways for repairing Top1 replicative damage.PMID 12368472Read ↗

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