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Article

Tyrosyl-DNA phosphodiesterase (Tdp1) participates in the repair of Top2-mediated DNA damage.

Proceedings of the National Academy of Sciences of the United States of America - 13 Jun 2006

Nitiss Karin C, Malik Mobeen, He Xiaoping, White Stephen W, Nitiss John L

Abstract excerpt

Agents targeting topoisomerases are active against a wide range of human tumors. Stabilization of covalent complexes, converting topoisomerases into DNA-damaging agents, is an essential aspect of cell killing by these drugs. A unique aspect of the repair of topoisomerase-mediated DNA damage is the requirement for pathways that can remove protein covalently bound to DNA. Tyrosyl-DNA phosphodiesterase (Tdp1) is an...

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Identifiers

PMID: 16751265
DOI: 10.1073/pnas.0603455103
PMCID: PMC1482547

Genes

TDP1
TOP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Tyrosyl-DNA phosphodiesterase (Tdp1) participates in the repair of Top2-mediated DNA damage.PMID 16751265Read ↗

TDP2 promotes repair of topoisomerase I-mediated DNA damage in the absence of TDP1Semantic proximity Read ↗

Mutation of a conserved active site residue converts tyrosyl-DNA phosphodiesterase I into a DNA topoisomerase I-dependent poison.Semantic proximity Read ↗

Human Tdp1 cleaves a broad spectrum of substrates, including phosphoamide linkages.Semantic proximity Read ↗

Development of an oligonucleotide-based fluorescence assay for the identification of tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitors.Semantic proximity Read ↗

Identification of tyrosyl-DNA phosphodiesterase as a novel DNA damage repair enzyme in Arabidopsis.Semantic proximity Read ↗

Yeast gene for a Tyr-DNA phosphodiesterase that repairs topoisomerase I complexes.Semantic proximity Read ↗

Epigenetic and genetic inactivation of tyrosyl-DNA-phosphodiesterase 1 (TDP1) in human lung cancer cells from the NCI-60 panel.Semantic proximity Read ↗

Tyrosyl-DNA phosphodiesterase 1 (TDP1) and SPRTN protease repair histone 3 and topoisomerase 1 DNA-protein crosslinks <i>in vivo</i>Semantic proximity Read ↗

TDP2–Dependent Non-Homologous End-Joining Protects against Topoisomerase II–Induced DNA Breaks and Genome Instability in Cells and In VivoSemantic proximity Read ↗

The role of TDP1 from budding yeast in the repair of DNA damage.Semantic proximity Read ↗

Topoisomerase 3B (TOP3B) DNA and RNA Cleavage Complexes and Pathway to Repair TOP3B-linked RNA and DNA BreaksSemantic proximity Read ↗

Trapped Topoisomerase II initiates formation of <i>de novo</i> duplications <i>via</i> the nonhomologous end-joining pathway in yeastSemantic proximity Read ↗

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