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Article

Transcription bypass of DNA lesions enhances cell survival but attenuates transcription coupled DNA repair.

Nucleic acids research - 1 Dec 2014

Li Wentao, Selvam Kathiresan, Ko Tengyu, Li Shisheng

Abstract excerpt

Transcription-coupled DNA repair (TCR) is a subpathway of nucleotide excision repair (NER) dedicated to rapid removal of DNA lesions in the transcribed strand of actively transcribed genes. The precise nature of the TCR signal and how the repair machinery gains access to lesions imbedded in stalled RNA polymerase II (RNAP II) complexes in eukaryotic cells are still enigmatic. RNAP II has an intrinsic capacity for...

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Identifiers

PMID: 25389266
DOI: 10.1093/nar/gku1150
PMCID: PMC4245964

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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