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Article

Yeast gene for a Tyr-DNA phosphodiesterase that repairs topoisomerase I complexes.

Science (New York, N.Y.) - 15 Oct 1999

Pouliot J J, Yao K C, Robertson C A, Nash H A

Abstract excerpt

Covalent intermediates between topoisomerase I and DNA can become dead-end complexes that lead to cell death. Here, the isolation of the gene for an enzyme that can hydrolyze the bond between this protein and DNA is described. Enzyme-defective mutants of yeast are hypersensitive to treatments that increase the amount of covalent complexes, indicative of enzyme involvement in repair. The gene is conserved in...

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Identifiers

PMID: 10521354
DOI: 10.1126/science.286.5439.552

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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