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Article

The role of TDP1 from budding yeast in the repair of DNA damage.

DNA repair - 3 Jun 2004

Liu Chunyan, Pouliot Jeffrey J, Nash Howard A

Abstract excerpt

The TDP1 gene encodes a protein that can hydrolyze certain types of 3'-terminal phosphodiesters, but the relevance of these catalytic activities to gene function has not been previously tested. In this work we engineered a point mutation in TDP1 and present evidence that, as per design, it severely diminishes tyrosyl-DNA phosphodiesterase enzyme activity without affecting protein folding. The phenotypes of yeast...

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Source

Identifiers

PMID: 15135727
DOI: 10.1016/j.dnarep.2004.03.030

Genes

TDP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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