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Article

Precipitated withdrawal following codeine administration is dependent on CYP genotype.

European journal of pharmacology - 17 Aug 2001

Chew M, White J M, Somogyi A A, Bochner F, Irvine R J

Abstract excerpt

The role of metabolic polymorphism in the development of physical dependence to codeine was assessed in cytochrome P450 2D2 (CYP2D2) deficient Dark Agouti and CYP2D2 intact Sprague-Dawley rats by assessment of the severity of naloxone precipitated withdrawal after codeine and morphine administration. Plasma morphine concentrations after codeine were significantly higher (P<0.01) in Sprague-Dawley than in Dark...

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Source

Identifiers

PMID: 11513833
DOI: 10.1016/s0014-2999(01)01185-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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