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Article

Codeine intoxication associated with ultrarapid CYP2D6 metabolism.

The New England journal of medicine - 30 Dec 2004

Gasche Yvan, Daali Youssef, Fathi Marc, Chiappe Alberto, Cottini Silvia, Dayer Pierre, Desmeules Jules

Abstract excerpt

Life-threatening opioid intoxication developed in a patient after he was given small doses of codeine for the treatment of a cough associated with bilateral pneumonia. Codeine is bioactivated by CYP2D6 into morphine, which then undergoes further glucuronidation. CYP2D6 genotyping showed that the patient had three or more functional alleles, a finding consistent with ultrarapid metabolism of codeine. We attribute...

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Source

Identifiers

PMID: 15625333
DOI: 10.1056/NEJMoa041888

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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