Codeine intoxication associated with ultrarapid CYP2D6 metabolism.

doi:10.1056/NEJMoa041888

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Article

Codeine intoxication associated with ultrarapid CYP2D6 metabolism.

The New England journal of medicine - 30 Dec 2004

Gasche Yvan, Daali Youssef, Fathi Marc, Chiappe Alberto, Cottini Silvia, Dayer Pierre, Desmeules Jules

Abstract excerpt

Life-threatening opioid intoxication developed in a patient after he was given small doses of codeine for the treatment of a cough associated with bilateral pneumonia. Codeine is bioactivated by CYP2D6 into morphine, which then undergoes further glucuronidation. CYP2D6 genotyping showed that the patient had three or more functional alleles, a finding consistent with ultrarapid metabolism of codeine. We attribute...

Topics

Analgesics, Opioid
Antitussive Agents
Codeine
Cough
Cytochrome P-450 CYP2D6
Cytochrome P-450 CYP3A
Cytochrome P-450 Enzyme System
Dextromethorphan
Genotype
Humans
Lung Diseases, Fungal
Male
Methylation
Middle Aged
Phenotype
Pneumonia

Source

Open in PubMed

Identifiers

PMID: 15625333
DOI: 10.1056/NEJMoa041888

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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