Article
The hyperthermic and neurotoxic effects of 'Ecstasy' (MDMA) and 3,4 methylenedioxyamphetamine (MDA) in the Dark Agouti (DA) rat, a model of the CYP2D6 poor metabolizer phenotype.
British journal of pharmacology - 1 Aug 1995
Colado M I, Williams J L, Green A R
Abstract excerpt
1. The effect of administration of 3,4-methylenedioxymethamphetamine (MDMA or 'Ecstasy') and its N-demethylated product, 3,4-methylenedioxyamphetamine (MDA) on both rectal temperature and long term neurotoxic loss of cerebral 5-hydroxytryptamine (5-HT) has been studied in male and female Dark Agouti (DA) rats. The female metabolizes debrisoquine more slowly than the male and its use has been suggested as a model...
Topics
- 3,4-Methylenedioxyamphetamine
- Animals
- Body Temperature Regulation
- Brain
- Cytochrome P-450 CYP2D6
- Cytochrome P-450 Enzyme System
- Female
- Fever
- Humans
- Hydroxyindoleacetic Acid