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Article

Biological sex influences sleep phenotype in mice experiencing spontaneous opioid withdrawal.

Journal of sleep research - 1 May 2024

Tisdale Ryan K, Sun Yu, Park Sunmee, Ma Shun-Chieh, Haire Meghan, Allocca Giancarlo, Bruchas Michael R, Morairty Stephen R, Kilduff Thomas S

Abstract excerpt

Aversive symptoms, including insomnia experienced during opioid withdrawal, are a major drive to relapse; however, withdrawal-associated sleep symptomatology has been little explored in preclinical models. We describe here a model of opioid withdrawal in mice that resembles the sleep phenotype characteristic of withdrawal in humans. Male and female C57BL/6 mice were instrumented with telemeters to record...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37731248
DOI: 10.1111/jsr.14037
PMCID: PMC10950840

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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