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Article

An essential role for BAFF in the normal development of B cells through a BCMA-independent pathway.

Science (New York, N.Y.) - 14 Sept 2001

Schiemann B, Gommerman J L, Vora K, Cachero T G, Shulga-Morskaya S, Dobles M, Frew E, Scott M L

Abstract excerpt

The B cell activating factor BAFF (BlyS/TALL-1/zTNF4) is a tumor necrosis factor (TNF)-related ligand that promotes B cell survival and binds to three receptors (BCMA, TACI, and the recently described BAFF-R). Here we report an absolute requirement for BAFF in normal B cell development. Examination of secondary lymphoid organs from BAFF-deficient mice revealed an almost complete loss of follicular and marginal...

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Source

Identifiers

PMID: 11509691
DOI: 10.1126/science.1061964

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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An essential role for BAFF in the normal development of B cells through a BCMA-independent pathway.PMID 11509691Read ↗

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BAFF-driven autoimmunity requires CD19 expression.Semantic proximity Read ↗

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Deficiency in TNFRSF13B (TACI) expands T-follicular helper and germinal center B cells via increased ICOS-ligand expression but impairs plasma cell survival.Semantic proximity Read ↗

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