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Article

B cell maturation antigen deficiency exacerbates lymphoproliferation and autoimmunity in murine lupus.

Journal of immunology (Baltimore, Md. : 1950) - 1 Jun 2011

Jiang Chao, Loo William M, Greenley Erin J, Tung Kenneth S, Erickson Loren D

Abstract excerpt

Systemic lupus erythematosus and its preclinical lupus-prone mouse models are autoimmune disorders involving the production of pathogenic autoantibodies. Genetic predisposition to systemic lupus erythematosus results in B cell hyperactivity, survival of self-reactive B cells, and differentiation to autoantibody-secreting plasma cells (PCs). These corrupt B cell responses are, in part, controlled by excess levels...

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Identifiers

PMID: 21536804
DOI: 10.4049/jimmunol.1001931
PMCID: PMC3181142

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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