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Article

APRIL-deficient mice have normal immune system development.

Molecular and cellular biology - 1 Feb 2004

Varfolomeev Eugene, Kischkel Frank, Martin Flavius, Seshasayee Dhaya, Wang Hua, Lawrence David, Olsson Christine, Tom Lucrece, Erickson Sharon, French Dorothy, Schow Peter, Grewal Iqbal S, Ashkenazi Avi

Abstract excerpt

APRIL (a proliferation-inducing ligand) is a member of the tumor necrosis factor (TNF) superfamily. APRIL mRNA shows high levels of expression in tumors of different origin and a low level of expression in normal cells. APRIL shares two TNF receptor family members, TACI and BCMA, with another TNF...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 14729948
DOI: 10.1128/MCB.24.3.997-1006.2004
PMCID: PMC321448

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-14729948-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

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APRIL-deficient mice have normal immune system development.PMID 14729948Read ↗

An essential role for BAFF in the normal development of B cells through a BCMA-independent pathway.Semantic proximity Read ↗

Impaired IgA class switching in APRIL-deficient mice.Semantic proximity Read ↗

TACI‐dependent APRIL signaling maintains autoreactive B cells in a mouse model of systemic lupus erythematosusSemantic proximity Read ↗

TACI-Ig neutralizes molecules critical for B cell development and autoimmune disease. impaired B cell maturation in mice lacking BLyS.Semantic proximity Read ↗

Role of the APRIL molecule in solid tumorsSemantic proximity Read ↗

Mutation of the BAFF furin cleavage site impairs B-cell homeostasis and antibody responses.Semantic proximity Read ↗

T cell-specific gene targeting reveals that alpha4 is required for early T cell development.Semantic proximity Read ↗

TNF deficiency fails to protect BAFF transgenic mice against autoimmunity and reveals a predisposition to B cell lymphoma.Semantic proximity Read ↗

Mice deficient in MIM expression are predisposed to lymphomagenesis.Semantic proximity Read ↗

Ikaros is critical for B cell differentiation and function.Semantic proximity Read ↗

Lack of Ikaros Deregulates Inflammatory Gene Programs in T CellsSemantic proximity Read ↗

Deficiency in TNFRSF13B (TACI) expands T-follicular helper and germinal center B cells via increased ICOS-ligand expression but impairs plasma cell survival.Semantic proximity Read ↗

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