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Article

TNF deficiency fails to protect BAFF transgenic mice against autoimmunity and reveals a predisposition to B cell lymphoma.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jan 2004

Batten Marcel, Fletcher Carrie, Ng Lai Guan, Groom Joanna, Wheway Julie, Laâbi Yacine, Xin Xiaoguan, Schneider Pascal, Tschopp Jurg, Mackay Charles R, Mackay Fabienne

Abstract excerpt

TNF is well characterized as a mediator of inflammatory responses. TNF also facilitates organization of secondary lymphoid organs, particularly B cell follicles and germinal centers, a hallmark of T-dependent Ab responses. TNF also mediates defense against tumors. We examined the role of TNF in the development of inflammatory autoimmune disorders resembling systemic lupus erythematosus and Sjögren's syndrome...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 14707051
DOI: 10.4049/jimmunol.172.2.812

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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TNF deficiency fails to protect BAFF transgenic mice against autoimmunity and reveals a predisposition to B cell lymphoma.PMID 14707051Read ↗

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