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Article

Deficiency in TNFRSF13B (TACI) expands T-follicular helper and germinal center B cells via increased ICOS-ligand expression but impairs plasma cell survival.

Proceedings of the National Academy of Sciences of the United States of America - 18 Sept 2012

Ou Xijun, Xu Shengli, Lam Kong-Peng

Abstract excerpt

Mutations in TNFRSF13B, better known as transmembrane activator and calcium modulator and cyclophilin ligand interactor (TACI), contribute to common variable immunodeficiency and autoimmunity in humans. How TACI regulates these two opposing conditions is unclear, however. TACI binds the cytokines BAFF and APRIL, and previous studies using gene KO mice indicated that loss of TACI affected only T-cell-independent...

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Share to Autoimmunity
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Inducible T-Cell Co-Stimulator Protein

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Share to Receptors, Tumor Necrosis Factor

Share to T-Lymphocytes, Helper-Inducer

Share to Transmembrane Activator and CAML Interactor Protein

Source

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Identifiers

PMID: 22949644
DOI: 10.1073/pnas.1200386109
PMCID: PMC3458353

Genes

ICOS

Provenance

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Deficiency in TNFRSF13B (TACI) expands T-follicular helper and germinal center B cells via increased ICOS-ligand expression but impairs plasma cell survival.PMID 22949644Read ↗

Loss of TACI causes fatal lymphoproliferation and autoimmunity, establishing TACI as an inhibitory BLyS receptor.Semantic proximity Read ↗

The C76R transmembrane activator and calcium modulator cyclophilin ligand interactor mutation disrupts antibody production and B-cell homeostasis in heterozygous and homozygous mice.Semantic proximity Read ↗

TACItly changing tunes: farewell to a yin and yang of BAFF receptor and TACI in humoral immunity? New genetic defects in common variable immunodeficiency.Semantic proximity Read ↗

Mutations in TNFRSF13B encoding TACI are associated with common variable immunodeficiency in humans.Semantic proximity Read ↗

TACI-Ig neutralizes molecules critical for B cell development and autoimmune disease. impaired B cell maturation in mice lacking BLyS.Semantic proximity Read ↗

Integrated B Cell, Toll-like, and BAFF Receptor Signals Promote Autoantibody Production by Transitional B CellsSemantic proximity Read ↗

The C104R mutant impairs the function of transmembrane activator and calcium modulator and cyclophilin ligand interactor (TACI) through haploinsufficiency.Semantic proximity Read ↗

TACI‐dependent APRIL signaling maintains autoreactive B cells in a mouse model of systemic lupus erythematosusSemantic proximity Read ↗

FcγRIIb and BAFF differentially regulate peritoneal B1 cell survival.Semantic proximity Read ↗

TACI is mutant in common variable immunodeficiency and IgA deficiency.Semantic proximity Read ↗

Transmembrane activator and calcium-modulator and cyclophilin ligand interactor mutations in common variable immunodeficiency.Semantic proximity Read ↗

BCR and co-receptor crosstalk facilitate the positive selection of self-reactive transitional B cells.Semantic proximity Read ↗

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