Article
TACI-Ig neutralizes molecules critical for B cell development and autoimmune disease. impaired B cell maturation in mice lacking BLyS.
Immunity - 1 Aug 2001
Gross J A, Dillon S R, Mudri S, Johnston J, Littau A, Roque R, Rixon M, Schou O, Foley K P, Haugen H, McMillen S, Waggie K, Schreckhise R W, Shoemaker K, Vu T, Moore M, Grossman A, Clegg C H
Abstract excerpt
BLyS and APRIL have similar but distinct biological roles, mediated through two known TNF receptor family members, TACI and BCMA. We show that mice treated with TACI-Ig and TACI-Ig transgenic mice have fewer transitional T2 and mature B cells and reduced levels of circulating immunoglobulin. TACI...
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