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Article

Mutation of the BAFF furin cleavage site impairs B-cell homeostasis and antibody responses.

European journal of immunology - 1 Mar 2011

Bossen Claudia, Tardivel Aubry, Willen Laure, Fletcher Carrie A, Perroud Mai, Beermann Friedrich, Rolink Antonius G, Scott Martin L, Mackay Fabienne, Schneider Pascal

Abstract excerpt

B-cell-activating factor of the TNF family (BAFF)/BLyS contributes to B-cell homeostasis and function in the periphery. BAFF is expressed as a membrane-bound protein or released by proteolytic cleavage, but the functional importance of this processing event is poorly understood. Mice expressing BAFF with a mutated furin consensus cleavage site, i.e. furin-mutant BAFF (fmBAFF), were not different from...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21287546
DOI: 10.1002/eji.201040591

Genes

TNF

Provenance

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