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Article

BAFF and APRIL Receptors in B Cell Immunity and Autoimmunity.

Immunological reviews - 1 Sept 2026

Luff Daisy H, Schweighoffer Edina, Tybulewicz Victor L J

Abstract excerpt

BAFF and APRIL are TNF superfamily proteins that bind to BAFFR, TACI and BCMA, members of the TNF receptor superfamily. These proteins have both unique and overlapping roles in B cell development and survival and are major therapeutic targets for antibody- and B-cell-driven pathologies. BAFF and BAFFR are required for development and survival of follicular and marginal zone (MZ) B cells, whereas BAFF and APRIL...

Read the complete abstract on PubMed

Topics

Humans
Autoimmunity
Animals
B-Lymphocytes
Tumor Necrosis Factor Ligand Superfamily Member 13
B-Cell Activating Factor
B-Cell Activation Factor Receptor

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Transmembrane Activator and CAML Interactor Protein

B-Cell Maturation Antigen

Signal Transduction

Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 42755123
DOI: 10.1111/imr.70170
PMCID: PMC13586541

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

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