Genetic dissection of region around the Sa gene on rat chromosome 1: evidence for multiple loci affecting blood pressure.

doi:10.1161/01.hyp.38.2.216

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Article

Genetic dissection of region around the Sa gene on rat chromosome 1: evidence for multiple loci affecting blood pressure.

Hypertension (Dallas, Tex. : 1979) - 1 Aug 2001

Frantz S, Clemitson J R, Bihoreau M T, Gauguier D, Samani N J

Abstract excerpt

A region with a major effect on blood pressure (BP) is located on rat chromosome 1 in the vicinity of the Sa gene, a candidate gene for BP regulation. Previously, we observed a single linkage peak for BP in this region in second filial generation rats derived from a cross of the spontaneously hypertensive rat (SHR) with the Wistar-Kyoto rat (WKY), and we have reported the isolation of the region containing the BP...

Topics

Animals
Animals, Congenic
Blood Pressure
Chromosome Mapping
Coenzyme A Ligases
Genes
Genetic Predisposition to Disease
Hypertension
Proteins
Quantitative Trait, Heritable
Rats
Rats, Inbred SHR
Rats, Inbred WKY

Source

Open in PubMed

Identifiers

PMID: 11509479
DOI: 10.1161/01.hyp.38.2.216

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