Article
Isolation of a chromosome 1 region that contributes to high blood pressure and salt sensitivity.
Hypertension (Dallas, Tex. : 1979) - 1 Oct 1998
Iwai N, Tsujita Y, Kinoshita M
Abstract excerpt
Linkage analyses in the spontaneously hypertensive rat (SHR) suggest that a gene involved in blood pressure regulation may be located on rat chromosome 1, in the Sa region. To confirm this possibility, we replaced a region of chromosome 1 in the Wistar-Kyoto rat (WKY) defined by the markers D1Mit3 and MTPA with the corresponding chromosome segment from SHR. Genotyping using 65 polymorphic microsatellite markers...
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