Isolation of a chromosome 1 region that contributes to high blood pressure and salt sensitivity.

doi:10.1161/01.hyp.32.4.636

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Article

Isolation of a chromosome 1 region that contributes to high blood pressure and salt sensitivity.

Hypertension (Dallas, Tex. : 1979) - 1 Oct 1998

Iwai N, Tsujita Y, Kinoshita M

Abstract excerpt

Linkage analyses in the spontaneously hypertensive rat (SHR) suggest that a gene involved in blood pressure regulation may be located on rat chromosome 1, in the Sa region. To confirm this possibility, we replaced a region of chromosome 1 in the Wistar-Kyoto rat (WKY) defined by the markers D1Mit3 and MTPA with the corresponding chromosome segment from SHR. Genotyping using 65 polymorphic microsatellite markers...

Topics

Animals
Animals, Congenic
Blood Pressure
Chromosome Mapping
Genetic Markers
Genotype
Hypertension
Male
Phenotype
Rats
Rats, Inbred SHR
Rats, Inbred WKY
Sodium Chloride

Source

Open in PubMed

Identifiers

PMID: 9774355
DOI: 10.1161/01.hyp.32.4.636

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