Molecular genetics of the SA-gene: cosegregation with hypertension and mapping to rat chromosome 1.

doi:10.1097/00004872-199301000-00004

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Article

Molecular genetics of the SA-gene: cosegregation with hypertension and mapping to rat chromosome 1.

Journal of hypertension - 1 Jan 1993

Lindpaintner K, Hilbert P, Ganten D, Nadal-Ginard B, Inagami T, Iwai N

Abstract excerpt

OBJECTIVES: The SA-gene shows markedly higher levels of expression in the kidneys of spontaneously hypertensive rats (SHR) than in their non-hypertensive reference strain, the Wistar-Kyoto (WKY) rat. Based on the important role of the kidney in blood pressure regulation, the possibility has been...

Topics

Animals
Chromosome Mapping
Female
Genetic Linkage
Humans
Hypertension
Male
Phenotype
Polymorphism, Restriction Fragment Length
Rats
Rats, Inbred SHR
Rats, Inbred WKY

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