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Article

Genetic mapping of a gene causing hypertension in the stroke-prone spontaneously hypertensive rat.

Cell - 4 Oct 1991

Jacob H J, Lindpaintner K, Lincoln S E, Kusumi K, Bunker R K, Mao Y P, Ganten D, Dzau V J, Lander E S

Abstract excerpt

The stroke-prone spontaneously hypertensive rat (SHRSP) is a well-characterized model for primary hypertension in humans. High blood pressure in SHRSP shows polygenic inheritance, but none of the loci responsible have previously been identified. To locate genes controlling this quantitative trait, we mapped a large collection of DNA polymorphisms in a cross between SHRSP and the normotensive WKY strain. Here we...

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PMID: 1655275
DOI: 10.1016/0092-8674(91)90584-l

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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