Article
Genetic mapping of a gene causing hypertension in the stroke-prone spontaneously hypertensive rat.
Cell - 4 Oct 1991
Jacob H J, Lindpaintner K, Lincoln S E, Kusumi K, Bunker R K, Mao Y P, Ganten D, Dzau V J, Lander E S
Abstract excerpt
The stroke-prone spontaneously hypertensive rat (SHRSP) is a well-characterized model for primary hypertension in humans. High blood pressure in SHRSP shows polygenic inheritance, but none of the loci responsible have previously been identified. To locate genes controlling this quantitative trait...
Topics
- Animals
- Base Sequence
- Blood Pressure
- Cerebrovascular Disorders
- Chromosome Mapping
- Crosses, Genetic
- Female
- Genetic Linkage
- Genotype
- Hypertension
- Lod Score
- Male
- Molecular Sequence Data
- Oligodeoxyribonucleotides
- Peptidyl-Dipeptidase A