Article
Genetic analysis of rat chromosome 1 and the Sa gene in spontaneous hypertension.
Hypertension (Dallas, Tex. : 1979) - 1 Jan 2000
St Lezin E, Liu W, Wang J M, Yang Y, Qi N, Kren V, Zidek V, Kurtz T W, Pravenec M
Abstract excerpt
Linkage studies in segregating populations derived from the spontaneously hypertensive rat (SHR) indicate that a blood pressure quantitative trait locus exists on rat chromosome 1 in the vicinity of the Sa gene. On the basis of these findings and the observation of increased renal expression of the Sa gene in SHR versus normotensive rats, the Sa gene has been proposed as a candidate gene for spontaneous...
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