Article
Molecular dynamics simulations of wild-type and mutant forms of the Mycobacterium tuberculosis MscL channel.
Biophysical journal - 1 Sept 2001
Elmore D E, Dougherty D A
Abstract excerpt
The crystal structure of the Mycobacterium tuberculosis homolog of the bacterial mechanosensitive channel of large conductance (Tb-MscL) provides a unique opportunity to consider mechanosensitive signal transduction at the atomic level. Molecular dynamics simulations of the Tb-MscL channel embedded in an explicit lipid bilayer and of its C-terminal helical bundle alone in aqueous solvent were performed....
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