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Article

Skeletal muscle cells and adipocytes differ in their reliance on TC10 and Rac for insulin-induced actin remodeling.

Molecular endocrinology (Baltimore, Md.) - 1 Feb 2004

JeBailey Lellean, Rudich Assaf, Huang Xudong, Di Ciano-Oliveira Caterina, Kapus András, Klip Amira

Abstract excerpt

Insulin causes distinct cortical actin remodeling in muscle and fat cells, and interfering with actin dynamics halts glucose transporter 4 (GLUT4) translocation to the membrane. Phosphatidylinositol 3-kinase (PI3-K) and the small G protein Rac govern myocyte actin remodeling, whereas TC10 alpha contributes to adipocyte actin dynamics downstream of Cbl-associated protein (CAP) and Cbl, independently of PI3-K....

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Share to Adipocytes
Share to Glucose Transporter Type 4

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Guanosine Triphosphate

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Share to Proto-Oncogene Proteins c-cbl

Share to rac GTP-Binding Proteins

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Source

Identifiers

PMID: 14615606
DOI: 10.1210/me.2003-0294

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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