Article
Caveolin-1 regulates cellular trafficking and function of the glucagon-like Peptide 1 receptor.
Molecular endocrinology (Baltimore, Md.) - 1 Dec 2006
Syme Colin A, Zhang Lei, Bisello Alessandro
Abstract excerpt
The glucagon-like peptide 1 receptor (GLP-1R) mediates important effects on beta-cell function and glucose homeostasis and is one of the most promising therapeutic targets for type 2, and possibly type 1, diabetes. Yet, little is known regarding the molecular and cellular mechanisms that regulate its function. Therefore, we examined the cellular trafficking of the GLP-1R and the relation between receptor...
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