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Article

Caveolin-2 regulation of STAT3 transcriptional activation in response to insulin.

Biochimica et biophysica acta - 1 Jul 2009

Kwon Hayeong, Jeong Kyuho, Hwang Eun Mi, Park Jae-Yong, Hong Seong-Geun, Choi Wan-Sung, Pak Yunbae

Abstract excerpt

The regulatory function of caveolin-2 in signal transducer and activator of transcription 3 (STAT3) signaling by insulin was investigated. Insulin-induced increase in phosphorylation of STAT3 was reduced by caveolin-2 siRNA. Mutagenesis studies identified that phosphorylation of tyrosines 19 and 27 on caveolin-2 is required for the STAT3 activation. Caveolin-2 Y27A mutation decreased insulin-induced...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19427337
DOI: 10.1016/j.bbamcr.2009.04.015

Genes

STAT3

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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