Article
Rab10 in insulin-stimulated GLUT4 translocation.
The Biochemical journal - 1 Apr 2008
Sano Hiroyuki, Roach William G, Peck Grantley R, Fukuda Mitsunori, Lienhard Gustav E
Abstract excerpt
In fat and muscle cells, insulin stimulates the movement to and fusion of intracellular vesicles containing GLUT4 with the plasma membrane, a process referred to as GLUT4 translocation. Previous studies have indicated that Akt [also known as PKB (protein kinase B)] phosphorylation of AS160, a GAP (GTPase-activating protein) for Rabs, is required for GLUT4 translocation. The results suggest that this...
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