Article
Requirement of atypical protein kinase clambda for insulin stimulation of glucose uptake but not for Akt activation in 3T3-L1 adipocytes.
Molecular and cellular biology - 1 Dec 1998
Kotani K, Ogawa W, Matsumoto M, Kitamura T, Sakaue H, Hino Y, Miyake K, Sano W, Akimoto K, Ohno S, Kasuga M
Abstract excerpt
Phosphoinositide (PI) 3-kinase contributes to a wide variety of biological actions, including insulin stimulation of glucose transport in adipocytes. Both Akt (protein kinase B), a serine-threonine kinase with a pleckstrin homology domain, and atypical isoforms of protein kinase C (PKCzeta and PK...
Topics
- 3T3 Cells
- Adenoviridae
- Adipocytes
- Androstadienes
- Animals
- COS Cells
- Enzyme Activation
- Fluorescent Antibody Technique
- Glucose
- Glucose Transporter Type 4
- Insulin
- Isoenzymes
- Mice
- Monosaccharide Transport Proteins