Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Brucella abortus HtrA functions as an authentic stress response protease but is not required for wild-type virulence in BALB/c mice.

Infection and immunity - 1 Sept 2001

Phillips R W, Roop R M

Abstract excerpt

A second mutation has recently been identified in the previously described Brucella abortus htrA mutant PHE1. As a result of this finding, a new B. abortus htrA mutant, designated RWP11, was constructed to evaluate the biological function of the Brucella HtrA protease. RWP11 is more sensitive to oxidative killing in vitro and less resistant to killing by cultured murine neutrophils and macrophages than the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brucella abortus
Share to Brucellosis
Share to Heat-Shock Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Macrophages

Share to Mice, Inbred BALB C

Share to Periplasmic Proteins

Share to Serine Endopeptidases

Share to Spleen

Source

Open in PubMed Open full text

Identifiers

PMID: 11500472
DOI: 10.1128/IAI.69.9.5911-5913.2001
PMCID: PMC98712

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Brucella abortus HtrA functions as an authentic stress response protease but is not required for wild-type virulence in BALB/c mice.PMID 11500472Read ↗

The HtrA stress response protease contributes to resistance of Brucella abortus to killing by murine phagocytes.Semantic proximity Read ↗

The Brucella abortus Lon functions as a generalized stress response protease and is required for wild-type virulence in BALB/c mice.Semantic proximity Read ↗

A Brucella melitensis high temperature requirement A (htrA) deletion mutant demonstrates a stress response defective phenotype in vitro and transient attenuation in the BALB/c mouse model.Semantic proximity Read ↗

Re-examination of the role of the Brucella melitensis HtrA stress response protease in virulence in pregnant goats.Semantic proximity Read ↗

Cloning, characterization and construction of htrA and htrA-like mutants of Brucella abortus and their survival in BALB/c mice.Semantic proximity Read ↗

Characterization and genetic complementation of a Brucella abortus high-temperature-requirement A (htrA) deletion mutant.Semantic proximity Read ↗

HtrA, a Temperature- and Stationary Phase-Activated Protease Involved in Maturation of a Key Microbial Virulence Determinant, Facilitates Borrelia burgdorferi Infection in Mammalian HostsSemantic proximity Read ↗

HtrA Protease Family as Therapeutic TargetsSemantic proximity Read ↗

Gain-of-function study reveals the pleiotropic roles of serine protease HtrA in <i>Borrelia burgdorferi</i>Semantic proximity Read ↗

Brucella abortus ΔrpoE1 confers protective immunity against wild type challenge in a mouse model of brucellosis.Semantic proximity Read ↗

Comparative Analysis of the Roles of HtrA-Like Surface Proteases in Two Virulent Staphylococcus aureus StrainsSemantic proximity Read ↗

In vitro and in vivo phenotypes resulting from deletion of the high temperature requirement A (htrA) gene from the bovine vaccine strain Brucella abortus S19.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.