Article

Gain-of-function study reveals the pleiotropic roles of serine protease HtrA in <i>Borrelia burgdorferi</i>

2024-08-28

Abstract excerpt

<h4>ABSTRACT</h4> High-temperature requirement protease A (HtrA) is a family of serine proteases degrading misfolded and damaged proteins that are toxic to bacteria. The Lyme disease agent Borrelia burgdorferi encodes a single HtrA (BbHtrA). Previous studies have shown that BbHtrA is a key virulence determinant of B. burgdorferi as a deletion mutant of htrA ( ΔhtrA ) fails to establish infection in mice. Howe...

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Literature Corpus work: 8a32c1ec-48ba-5f83-8dc5-fa52d7028b59
DOI: 10.1101/2024.08.28.610130

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