The HtrA stress response protease contributes to resistance of Brucella abortus to killing by murine phagocytes.

doi:10.1128/iai.64.11.4838-4841.1996

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Article

The HtrA stress response protease contributes to resistance of Brucella abortus to killing by murine phagocytes.

Infection and immunity - 1 Nov 1996

Elzer P H, Phillips R W, Robertson G T, Roop R M

Abstract excerpt

Compared with virulent Brucella abortus 2308, the isogenic htrA mutant PHE1 shows decreased resistance to killing by cultured murine neutrophils and macrophages and significant attenuation during the early stages of infection in the BALB/c mouse model. These findings further define the contributi...

Topics

Animals
Bacterial Proteins
Brucella abortus
Brucellosis
Cells, Cultured
Heat-Shock Proteins
Macrophages
Mice
Mice, Inbred BALB C
Mutation
Neutrophils
Periplasmic Proteins
Phagocytes
Serine Endopeptidases
Virulence

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