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Article

Brucella abortus ΔrpoE1 confers protective immunity against wild type challenge in a mouse model of brucellosis.

Vaccine - 30 Sept 2016

Willett Jonathan W, Herrou Julien, Czyz Daniel M, Cheng Jason X, Crosson Sean

Abstract excerpt

The Brucella abortus general stress response (GSR) system regulates activity of the alternative sigma factor, σ(E1), which controls transcription of approximately 100 genes and is required for persistence in a BALB/c mouse chronic infection model. We evaluated the host response to infection by a B. abortus strain lacking σ(E1) (ΔrpoE1), and identified pathological and immunological features that distinguish...

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Source

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Identifiers

PMID: 27591954
DOI: 10.1016/j.vaccine.2016.08.076
PMCID: PMC5026968

Genes

GSR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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