Article
A Brucella melitensis high temperature requirement A (htrA) deletion mutant demonstrates a stress response defective phenotype in vitro and transient attenuation in the BALB/c mouse model.
Microbial pathogenesis - 1 Nov 1995
Phillips R W, Elzer P H, Roop RM I I
Abstract excerpt
Bacterial stress response proteins of the high temperature requirement A (HtrA) family are serine proteases which appear to play an important role in scavenging oxidatively damaged proteins from the cell before they reach toxic levels. An isogenic htrA deletion mutant, designated RWP5, was constr...
Topics
- Animals
- Brucella melitensis
- Gene Deletion
- Genes, Bacterial
- Heat-Shock Proteins
- Hydrogen Peroxide
- Mice
- Mice, Inbred BALB C
- Mutation
- Periplasmic Proteins
- Phenotype
- Puromycin
- Serine Endopeptidases
- Virulence