Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

RasC is required for optimal activation of adenylyl cyclase and Akt/PKB during aggregation.

The EMBO journal - 15 Aug 2001

Lim C J, Spiegelman G B, Weeks G

Abstract excerpt

Disruption of Dictyostelium rasC, encoding a Ras subfamily protein, generated cells incapable of aggregation. While rasC expression is enriched in a cell type-specific manner during post-aggregative development, the defect in rasC(-) cells is restricted to aggregation and fully corrected by application of exogenous cAMP pulses. cAMP is not produced in rasC(-) cells stimulated by 2'-deoxy-cAMP, but is produced in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenylyl Cyclases
Share to Chemotaxis
Share to Cyclic AMP

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Dictyostelium

Share to Mitogen-Activated Protein Kinase 1

Share to Phosphatidylinositol 3-Kinases

Share to Proto-Oncogene Proteins c-akt

Share to Receptors, Cyclic AMP

Source

Open in PubMed Open full text

Identifiers

PMID: 11500376
DOI: 10.1093/emboj/20.16.4490
PMCID: PMC125575

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

RasC is required for optimal activation of adenylyl cyclase and Akt/PKB during aggregation.PMID 11500376Read ↗

A secondary disruption of the dmpA gene encoding a large membrane protein allows aggregation defective Dictyostelium rasC- cells to form multicellular structures.Semantic proximity Read ↗

Determinants of RasC specificity during Dictyostelium aggregation.Semantic proximity Read ↗

A novel Ras-interacting protein required for chemotaxis and cyclic adenosine monophosphate signal relay in Dictyostelium.Semantic proximity Read ↗

Multiple developmental roles for CRAC, a cytosolic regulator of adenylyl cyclase.Semantic proximity Read ↗

An adenylyl cyclase that functions during late development of Dictyostelium.Semantic proximity Read ↗

Chemoattractant-induced Ras activation during Dictyostelium aggregation.Semantic proximity Read ↗

A novel Dictyostelium RasGEF required for chemotaxis and development.Semantic proximity Read ↗

RasC plays a role in transduction of temporal gradient information in the cyclic-AMP wave of Dictyostelium discoideum.Semantic proximity Read ↗

Dictyostelium RasG is required for normal motility and cytokinesis, but not growth.Semantic proximity Read ↗

Multiple roles for cAMP-dependent protein kinase during Dictyostelium development.Semantic proximity Read ↗

TOR complex 2 integrates cell movement during chemotaxis and signal relay in Dictyostelium.Semantic proximity Read ↗

cAMP production by adenylyl cyclase G induces prespore differentiation in Dictyostelium slugs.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.