Article
TOR complex 2 integrates cell movement during chemotaxis and signal relay in Dictyostelium.
Molecular biology of the cell - 1 Oct 2005
Lee Susan, Comer Frank I, Sasaki Atsuo, McLeod Ian X, Duong Yung, Okumura Koichi, Yates John R, Parent Carole A, Firtel Richard A
Abstract excerpt
Dictyostelium cells form a multicellular organism through the aggregation of independent cells. This process requires both chemotaxis and signal relay in which the chemoattractant cAMP activates adenylyl cyclase through the G protein-coupled cAMP receptor cAR1. cAMP is produced and secreted and it activates receptors on neighboring cells, thereby relaying the chemoattractant signal to distant cells. Using...
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