Article
Chemoattractant-induced Ras activation during Dictyostelium aggregation.
EMBO reports - 1 Jun 2004
Kae Helmut, Lim Chinten James, Spiegelman George B, Weeks Gerald
Abstract excerpt
Ras proteins are highly conserved molecular switches that regulate cellular response to external stimuli. Dictyostelium discoideum contains an extensive family of Ras proteins that function in regulation of mitosis, cytoskeletal function and motility, and the onset of development. Little is known about the events that lead to the activation of Ras proteins in Dictyostelium, primarily owing to a lack of a...
Topics
- Animals
- Biological Assay
- Cell Aggregation
- Cell Line
- Chemotactic Factors
- Cyclic AMP
- Dictyostelium
- Enzyme Activation
- MAP Kinase Kinase Kinases
- Mutation
- Protein Structure, Tertiary
- Proto-Oncogene Proteins c-raf
- Protozoan Proteins
- Schizosaccharomyces pombe Proteins
- ras Proteins