Article
Expression of alpha-catenin in alpha-catenin-deficient cells increases resistance to sphingosine-induced apoptosis.
The Journal of cell biology - 6 Aug 2001
Matsubara S, Ozawa M
Abstract excerpt
Alpha-catenin, an intracellular protein, associates with the COOH-terminal region of cadherin cell adhesion molecules through interactions with either beta-catenin or gamma-catenin (plakoglobin). The full activity of cadherins requires a linkage to the actin cytoskeleton mediated by catenins. We transfected alpha-catenin-deficient colon carcinoma cells with a series of alpha-catenin constructs to determine that...
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