Article
A mutation in alpha-catenin disrupts adhesion in clone A cells without perturbing its actin and beta-catenin binding activity.
Cell adhesion and communication - 1 Jun 1998
Roe S, Koslov E R, Rimm D L
Abstract excerpt
Cadherin mediated cell-cell adhesion requires cytoplasmic connections to the cytoskeleton mediated by alpha-catenin. Original descriptions of the catenins, as well as our own in vitro studies, have suggested that this connection was mediated by the interaction of alpha-catenin to actin. Loss of a...
Topics
- Actins
- Cadherins
- Cell Adhesion
- Cloning, Molecular
- Colonic Neoplasms
- Cytoskeletal Proteins
- Cytoskeleton
- Desmoplakins
- Exons
- HeLa Cells
- Humans
- Intercellular Junctions
- Mutation
- Octoxynol
- Precipitin Tests
- Protein Binding
- RNA, Messenger
- Recombinant Fusion Proteins