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Article

Nuclear translocation of beta-catenin in hereditary and carcinogen- induced intestinal adenomas

1 Apr 1998

Abstract excerpt

The physical interaction between beta-catenin and the adenomatous polyposis coli (APC) gene, and the ability of APC to regulate cytoplasmic levels of beta-catenin suggest a role for beta-catenin in colorectal carcinogenesis. In this study, we found that beta-catenin immunoreactivity was detected exclusively in the cell membrane and cytoplasm of morphologically normal intestinal epithelial cells with predominant...

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PMID: 9600336
DOI: 10.1093/carcin/19.4.543

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