Article
A truncated beta-catenin disrupts the interaction between E-cadherin and alpha-catenin: a cause of loss of intercellular adhesiveness in human cancer cell lines.
Cancer research - 1 Dec 1994
Oyama T, Kanai Y, Ochiai A, Akimoto S, Oda T, Yanagihara K, Nagafuchi A, Tsukita S, Shibamoto S, Ito F
Abstract excerpt
Cadherin cell adhesion molecules play an essential role in creating tight intercellular association and are considered to work as an invasion suppressor system of cancer cells. They form a molecular complex with catenins, a group of cytoplasmic proteins including alpha- and beta-catenins. While a...
Topics
- Animals
- Base Sequence
- Cadherins
- Cell Adhesion
- Cytoskeletal Proteins
- Humans
- Immunoblotting
- Mice
- Mice, Inbred BALB C
- Molecular Sequence Data
- Mutation
- Neoplasm Invasiveness
- Neoplasms
- Precipitin Tests
- RNA, Messenger