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Article

Target disruption of the mutant beta-catenin gene in colon cancer cell line HCT116: preservation of its malignant phenotype.

Oncogene - 29 Aug 2002

Sekine Shigeki, Shibata Tatsuhiro, Sakamoto Michiie, Hirohashi Setsuo

Abstract excerpt

Most colorectal carcinomas harbor genetic alterations that result in stabilization of beta-catenin. A colorectal carcinoma cell line, HCT116, which has both mutated and wild-type beta-catenin genes, was engineered by homologous recombination to investigate the significance of beta-catenin gene mutation. As expected, the mutant allele-targeted clones showed decreased beta-catenin expression and downregulation of...

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PMID: 12185590
DOI: 10.1038/sj.onc.1205756

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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