Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Exogenous expression of beta-catenin regulates contact inhibition, anchorage-independent growth, anoikis, and radiation-induced cell cycle arrest.

The Journal of cell biology - 23 Aug 1999

Orford K, Orford C C, Byers S W

Abstract excerpt

beta-Catenin is an important regulator of cell-cell adhesion and embryonic development that associates with and regulates the function of the LEF/TCF family of transcription factors. Mutations of beta-catenin and the tumor suppressor gene, adenomatous polyposis coli, occur in human cancers, but it is not known if, and by what mechanism, increased beta-catenin causes cellular transformation. This study...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to beta Catenin
Share to Cell Count
Share to Cell Size

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cytoskeletal Proteins

Share to Gamma Rays

Share to Interphase

Share to Oncogenes

Share to Transgenes

Source

Open in PubMed Open full text

Identifiers

PMID: 10459019
DOI: 10.1083/jcb.146.4.855
PMCID: PMC2156133

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Exogenous expression of beta-catenin regulates contact inhibition, anchorage-independent growth, anoikis, and radiation-induced cell cycle arrest.PMID 10459019Read ↗

Expression of alpha-catenin in alpha-catenin-deficient cells results in a reduced proliferation in three-dimensional multicellular spheroids but not in two-dimensional monolayer cultures.Semantic proximity Read ↗

Deregulated beta-catenin induces a p53- and ARF-dependent growth arrest and cooperates with Ras in transformation.Semantic proximity Read ↗

The oncogenic activation of beta-catenin.Semantic proximity Read ↗

Expression of alpha-catenin in alpha-catenin-deficient cells increases resistance to sphingosine-induced apoptosis.Semantic proximity Read ↗

A truncated beta-catenin disrupts the interaction between E-cadherin and alpha-catenin: a cause of loss of intercellular adhesiveness in human cancer cell lines.Semantic proximity Read ↗

gamma-catenin is regulated by the APC tumor suppressor and its oncogenic activity is distinct from that of beta-catenin.Semantic proximity Read ↗

Induction of a beta-catenin-LEF-1 complex by wnt-1 and transforming mutants of beta-catenin.Semantic proximity Read ↗

Maintenance of adenomatous polyposis coli (APC)-mutant colorectal cancer is dependent on Wnt/beta-catenin signaling.Semantic proximity Read ↗

Loss of β-catenin in adrenocortical cancer cells causes growth inhibition and reversal of epithelial-to-mesenchymal transition.Semantic proximity Read ↗

Oncogenic Mutants of RON and MET Receptor Tyrosine Kinases Cause Activation of the β-Catenin PathwaySemantic proximity Read ↗

Dysregulation of the E-cadherin/catenin complex by irreversible mutations in human carcinomas.Semantic proximity Read ↗

Small interfering RNAs directed against beta-catenin inhibit the in vitro and in vivo growth of colon cancer cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.