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Article

Modulation of the tumor suppressor protein alpha-catenin by ischemic microenvironment.

The American journal of pathology - 1 Oct 2009

Plumb Claire L, Adamcic Una, Shahrzad Siranoush, Minhas Kanwal, Adham Sirin A I, Coomber Brenda L

Abstract excerpt

Dysregulation or mislocalization of cell adhesion molecules and their regulators, such as E-cadherin, beta-catenin, and alpha-catenin, usually correlates with loss of polarity, dedifferentiation, invasive tumor growth, and metastasis. A subpopulation of alpha-catenin-negative cells within the DLD-1 colorectal carcinoma cell line causes it to display a heterogeneous morphological makeup, thus providing an...

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Identifiers

PMID: 19745064
DOI: 10.2353/ajpath.2009.090007
PMCID: PMC2751562

Genes

DLD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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