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Article

Mutant p53 cooperates with ETS and selectively up-regulates human MDR1 not MRP1.

The Journal of biological chemistry - 19 Oct 2001

Sampath J, Sun D, Kidd V J, Grenet J, Gandhi A, Shapiro L H, Wang Q, Zambetti G P, Schuetz J D

Abstract excerpt

The most frequently expressed drug resistance genes, MDR1 and MRP1, occur in human tumors with mutant p53. However, it was unknown if mutant p53 transcriptionally regulated both MDR1 and MRP1. We demonstrated that mutant p53 did not activate either the MRP1 promoter or the endogenous gene. In contrast, mutant p53 strongly up-regulated the MDR1 promoter and expression of the endogenous MDR1 gene. Notably, cells...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 11483599
DOI: 10.1074/jbc.M103429200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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