Article
Multidrug resistance related genes and p53 expression in human non small cell lung cancer.
Anticancer research - 1 Jan 2000
Galimberti S, Marchetti A, Buttitta F, Carnicelli V, Pellegrini S, Bevilacqua G, Petrini M
Abstract excerpt
BACKGROUND: Many genes (mdr1, mrp, DNA topoisomerases II) are known to be involved in the resistance to unrelated drugs (the MDR phenomenon), but the mechanisms of their activation have to be further investigated. MATERIALS AND METHODS: Because several authors showed that p53 mutated gene was abl...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Aged
- Antigens, Neoplasm
- Carcinoma, Non-Small-Cell Lung
- DNA Topoisomerases, Type II
- DNA-Binding Proteins
- Drug Resistance, Multiple
- Gene Expression Regulation, Neoplastic
- Genes, p53
- Humans
- Isoenzymes
- Lung Neoplasms
- Middle Aged
- Mutation
- Phenotype
- Polymerase Chain Reaction
- Transcription, Genetic
- Tumor Suppressor Protein p53