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Article

Cancer chemoresistance: The relationship between p53 and multidrug transporters

28 Feb 2002

Abstract excerpt

Extensive studies indicate that both p53 and multidrug transporters play important roles in chemoresistance. Since the initial reports a decade ago demonstrating a transcriptional dependence of the ABCB1 gene (MDR) promoter by p53, much data have been accumulated. However, despite being the subject of intense study, this p53-MDR relationship remains unclear in human cancers. The data are confounded by variable...

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PMID: 11920581
DOI: 10.1002/ijc.10226

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