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Article

Modulation of Activity of the Promoter of the Human <i>MDR</i> 1 Gene by Ras and p53

24 Jan 1992

Abstract excerpt

Drug resistance in human cancer is associated with overexpression of the multidrug resistance (MDR1) gene, which confers cross-resistance to hydrophobic natural product cytotoxic drugs. Expression of the MDR1 gene can occur de novo in human cancers in the absence of drug treatment. The promoter of the human MDR1 gene was shown to be a target for the c-Ha-Ras-1 oncogene and the p53 tumor suppressor gene products,...

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Identifiers

PMID: 1346476
DOI: 10.1126/science.1346476

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Modulation of Activity of the Promoter of the Human <i>MDR</i> 1 Gene by Ras and p53PMID 1346476Read ↗

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