Article
An etoposide-resistant lung cancer subline overexpresses the multidrug resistance-associated protein.
British journal of cancer - 1 Sept 1995
Doyle L A, Ross D D, Ordonez J V, Yang W, Gao Y, Tong Y, Belani C P, Gutheil J C
Abstract excerpt
We have characterised an etoposide-resistant subline of the small-cell lung cancer cell line, UMCC-1, derived at our centre. Subline UMCC-1/VP was developed by culturing the parent line in increasing concentrations of etoposide over 16 months. UMCC-1/VP is 20-fold resistant to etoposide by MTT assays, relative to the parent line, and is cross-resistant to doxorubicin, vincristine and actinomycin D, but not to...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- ATP-Binding Cassette Transporters
- Antineoplastic Agents
- Carcinoma, Small Cell
- DNA Topoisomerases, Type II
- Drug Resistance
- Drug Resistance, Multiple
- Etoposide
- Gene Expression
- Humans