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Article

p53 overexpression increases chemosensitivity in multidrug-resistant osteosarcoma cell lines.

Cancer chemotherapy and pharmacology - 1 Feb 2016

Ye Shunan, Shen Jacson, Choy Edwin, Yang Cao, Mankin Henry, Hornicek Francis, Duan Zhenfeng

Abstract excerpt

PURPOSE: Multidrug resistance (MDR) is a major obstacle to the successful treatment of osteosarcoma with chemotherapy. Effectiveness of cancer therapy correlates with the ability to induce a p53-dependent apoptotic response. p53 is a tumor suppressor gene that is mutated in 22 % of osteosarcomas. While impaired p53 has been implicated in the oncogenesis of osteosarcoma, it is unclear whether overexpression of...

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Identifiers

PMID: 26698867
DOI: 10.1007/s00280-015-2944-z
PMCID: PMC4749432

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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