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Article

Modulation of multidrug resistance-associated protein 1 (MRP1) by p53 mutant in Saos-2 cells.

Cancer chemotherapy and pharmacology - 1 Feb 2003

Tsang Wing-Pui, Chau Sophia P Y, Fung Kwok-Pui, Kong Siu-Kai, Kwok Tim-Tak

Abstract excerpt

The p53 tumor suppressor gene is one of the most frequently mutated genes in human cancer and the mutation is correlated with a poor prognosis in cancer therapy. Upregulation of multidrug resistance-associated protein 1 (MRP1) and increase in drug resistance have been found to be induced by p53 mutation. Human osteosarcoma Saos-2 cells, a p53-null cell line, was transfected with p53 with mutations at codon 143 (V...

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Identifiers

PMID: 12647018
DOI: 10.1007/s00280-002-0551-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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